|
KMID : 1134819970260010137
|
|
Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 1 p.137 ~ p.143
|
|
|
Effects of Godulbaegi Leaf Extracts on CCl₄ - Induced Hepatotoxicity in Rats
|
|
Bae Song-Ja
Jung Bok-Mi
Rho Sung-Bae
Kim Nam-Hong
Ha Bae-Jin
|
|
|
Abstract
|
|
|
|
This study was carried out to investigate the effect of godulbaegi leaf extracts on detoxication of liver injury in CCl₄-treated rats. We divided normal group(S) and CCl₄-treated group and then CCl₄-treated group was divided into 6 groups; only CCl₄-treated group(CS), aqueous extract pretreated group(CSA), n-butanol extract pretreated group(CSB), Tween 80 pretreated group(CT), n-hexane extract pretreated group(CTH) and ethyl acetate extract pretreated group(CTE). The ratio of liver weight per body weight and the activity of GPT in hexane extract group(CTH) were lowest, similar to the results of S. Godulbaegi n-hexane extract(IS) groups intoxicated by CCl₄ had lower values of MDA than CS and CT which are control groups. Histological finding of liver tissue revealed less of necrosis in IS extracts groups than in control groups(CS, CT). From these results, IS extracts could predominently prevent hepat-otoxicity of rats. Especially, hexane extract was effective on the detoxication of liver injury among the other extracts.
|
|
|
KEYWORD
|
|
|
Ixeris sonchifolia extracts, carbon tetrachloride, GPT, lipid peroxidation, antioxidant
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|